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Susana R. Cerqueira, Joaquim M. Oliveira, Nuno A. Silva, Hugo Leite-Almeida, Silvina Ribeiro-Samy, Armando Almeida, João F. Mano, Nuno Sousa, António J. Salgado and Rui L. Reis Microglia Response and In Vivo Therapeutic Potential of Methylprednisolone-Loaded Dendrimer Nanoparticles in Spinal Cord Injury Small 9

Version of Record online: 15 NOV 2012 | DOI: 10.1002/smll.201201888

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A surface-engineered carboxymethylchitosan/polyamidoamine (CMCht/PAMAM) dendrimer nanoparticle is presented as an intracellular delivery vehicle of methylprednisolone to glial cells, for spinal cord injury (SCI) repair. The local and sustained delivery following lateral hemisection in rats reveals significant improvements in the locomotor output of nanoparticle-treated animals, suggesting that this system can be valuable in the reduction of secondary injuries following SCI.

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