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Yucai Wang, Yi Wang, Fengbo Zhou, Paul Kim and Younan Xia Protein-Protected Au Clusters as a New Class of Nanoscale Biosensor for Label-Free Fluorescence Detection of Proteases Small 8

Article first published online: 12 SEP 2012 | DOI: 10.1002/smll.201201983

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Destruction for detection: Protein-protected Au clusters are exploited as nanoscale sensors for label-free fluorescence detection of proteases with high sensitivity. The detection mechanism is based on degradation of the protein shell by a protease, allowing the O2 from ambient air to penetrate through and quench the fluorescence from the Au cluster.

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