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Anna Pratsinis, Pablo Hervella, Jean-Christophe Leroux, Sotiris E. Pratsinis and Georgios A. Sotiriou Toxicity of Silver Nanoparticles in Macrophages Small 9

Article first published online: 18 FEB 2013 | DOI: 10.1002/smll.201202120

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The cytotoxicity of nanosilver against macrophages is investigated using precisely size-tuned nanosilver supported on nanostructured silica. Small (<10 nm) nanosilver releases a large fraction of its mass as Ag+ ions when compared to large nanosilver (>10 nm). Therefore, the toxicity of small nanosilver is mostly mediated by the released Ag+ ions. However, as the nanosilver size increases, direct silver nanoparticle–cell interactions dominate the toxicity.

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