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Jian Wang, Mingxu You, Guizhi Zhu, Mohammed Ibrahim Shukoor, Zhuo Chen, Zilong Zhao, Meghan B. Altman, Quan Yuan, Zhi Zhu, Yan Chen, Cheng Zhi Huang and Weihong Tan Photosensitizer–Gold Nanorod Composite for Targeted Multimodal Therapy Small 9

Article first published online: 10 MAY 2013 | DOI: 10.1002/smll.201202155

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A DNA inter-strand replacement strategy for therapeutic activity is successfully designed for multimodal therapy. Chlorin e6 (Ce6) photosensitizer molecules are used for photodynamic therapy, while aptamer-AuNRs, are used for selective binding to target cancer cells and for photothermal therapy with near infrared laser irradiation. The design was effective in killing target CEM cells, without harming non-target Ramos cells.

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