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Yun Wu, Megan Cavanaugh Terp, Kwang Joo Kwak, Daniel Gallego-Perez, Serge P. Nana-Sinkam and L. James Lee Surface-Mediated Nucleic Acid Delivery by Lipoplexes Prepared in Microwell Arrays Small 9

Article first published online: 8 MAR 2013 | DOI: 10.1002/smll.201202258

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Uniform lipoplexes containing nucleic acids are prepared in a microwell array by discontinuous dewetting in a facile and well controlled manner. The microwell array-mediated delivery of lipoplexes containing nucleic acids is more efficient than a conventional transfection method, and thus significantly enhances the therapeutic efficacy at much lower effective doses of therapeutic reagents. Microwell arrays are also a very flexible platform that can be used to deliver multifunctional lipoplexes for applications in theranostic medicine.

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