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Flavio Curnis, Angelina Sacchi, Renato Longhi, Barbara Colombo, Anna Gasparri and Angelo Corti IsoDGR-Tagged Albumin: A New αvβ3 Selective Carrier for Nanodrug Delivery to Tumors Small 9

Article first published online: 12 NOV 2012 | DOI: 10.1002/smll.201202310

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A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR-tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature-selective nanomedicines, such as gold nanoparticles (Au) carrying tumor necrosis factor α (TNF), a potent vascular damaging agent.

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