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Mark Kastantin and Daniel K. Schwartz DNA Hairpin Stabilization on a Hydrophobic Surface Small 9

Article first published online: 26 NOV 2012 | DOI: 10.1002/smll.201202335

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Single-molecule tracking at the solid–liquid interface is used to measure rates of conformational change in single-stranded DNA molecules that can undergo hairpin-coil transitions. Relative to a model hydrophobic surface (TMS), an oligo(ethylene glycol) (OEG) surface significantly slows the coil-to-hairpin (i.e., folding) rate while increasing the hairpin-to-coil (i.e., unfolding) rate. These results indicate that hydrophobic surface coatings better promote DNA hybridization.

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