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Junlong Geng, Kai Li, Wei Qin, Lin Ma, Gagik G. Gurzadyan, Ben Zhong Tang and Bin Liu Eccentric Loading of Fluorogen with Aggregation-Induced Emission in PLGA Matrix Increases Nanoparticle Fluorescence Quantum Yield for Targeted Cellular Imaging Small 9

Article first published online: 13 FEB 2013 | DOI: 10.1002/smll.201202505

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A simple strategy to control the location of fluorogens with aggregation-induced emission (AIE) characteristics in poly (DL-lactide-co-glycolide) (PLGA) nanoparticles is developed by changing the concentration of emulsifier, polyvinyl alcohol (PVA). The AIE fluorogens eccentrically loaded PLGA nanoparticles show a high quantum yield of 34%, good biocompatibility, and a far-red/near infrared fluorescence signature in aqueous conditions, which are ideal for cellular imaging.

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