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Meng Li, Can Xu, Li Wu, Jinsong Ren, Enbo Wang and Xiaogang Qu Self-Assembled Peptide–Polyoxometalate Hybrid Nanospheres: Two in One Enhances Targeted Inhibition of Amyloid β-Peptide Aggregation Associated with Alzheimer's Disease Small 9

Version of Record online: 6 MAY 2013 | DOI: 10.1002/smll.201202612

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A Wells–Dawson-type phosphotungstate is combined with Aβ15-20, an Aβ-targted peptide inhibitor, to assemble spherical nanoparticles. The two-in-one bifunctional POM@P nanoparticles show an enhanced targeting inhibition effect on amyloid aggregation in mice cerebrospinal fluid. Incorporating an Aβ fibril-specific staining dye into the sphere, the nanoparticle can act as a fluorescent probe to monitor the inhibition process in real time.

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