Lei Zhang, Andrew Sinclair, Zhiqiang Cao, Jean-Rene Ella-Menye, Xuewei Xu, Louisa R. Carr, Suzie H. Pun and Shaoyi Jiang Hydrolytic Cationic Ester Microparticles for Highly Efficient DNA Vaccine Delivery Small 9
Degradable hydrogel microparticles are prepared, utilizing esters containing quaternary amines for DNA adsorption and tertiary amines for phagosomal escape. After ester hydrolysis, the particles can shift to an ultra-low-fouling and nontoxic zwitterionic form; this can additionally facilitate the release of adsorbed DNA. Due to their micrometer size, the microparticles can passively target macrophage cells but avoid entering somatic cells.
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