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Nuoya Yin, Qian Liu, Jiyan Liu, Bin He, Lin Cui, Zhuona Li, Zhaojun Yun, Guangbo Qu, Sijin Liu, Qunfang Zhou and Guibin Jiang Silver Nanoparticle Exposure Attenuates the Viability of Rat Cerebellum Granule Cells through Apoptosis Coupled to Oxidative Stress Small 9

Version of Record online: 20 FEB 2013 | DOI: 10.1002/smll.201202732

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Silver nanoparticles (AgNPs) can induce significant cellular toxicity to cerebellum granule cells (CGCs). The apoptotic proportion of CGCs and caspase-3 activity increase in AgNP-treated groups compared to controls. AgNPs can also induce oxidative stress in CGCs. An in vivo test shows that AgNPs can provoke the destruction of the cerebellum granular layer with concomitant activation of caspase-3 after AgNP administration through intranasal instillation.

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