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Michele Iafisco, Josè Manuel Delgado-Lopez, Elena Maria Varoni, Anna Tampieri, Lia Rimondini, Jaime Gomez-Morales and Maria Prat Cell Surface Receptor Targeted Biomimetic Apatite Nanocrystals for Cancer Therapy Small 9

Article first published online: 18 APR 2013 | DOI: 10.1002/smll.201202843

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Apatite nanoparticles functionalized with the chemotherapeutic doxorubicin and a monoclonal antibody targeting tumor cells overexpressing the tumor associated marker Met/Hepatocyte Growth Factor receptor specifically bind to and are internalized in cells expressing the receptor, and discharge doxorubicin, which reaches the nucleus and exert cytotoxicity. This work opens new perspectives in the use of nanocrystalline apatites as new platform for theranostic applications in nanomedicine.

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