E-mail

E-mail a Wiley Online Library Link

Michele Iafisco, Josè Manuel Delgado-Lopez, Elena Maria Varoni, Anna Tampieri, Lia Rimondini, Jaime Gomez-Morales and Maria Prat Cell Surface Receptor Targeted Biomimetic Apatite Nanocrystals for Cancer Therapy Small 9

Article first published online: 18 APR 2013 | DOI: 10.1002/smll.201202843

Thumbnail image of graphical abstract

Apatite nanoparticles functionalized with the chemotherapeutic doxorubicin and a monoclonal antibody targeting tumor cells overexpressing the tumor associated marker Met/Hepatocyte Growth Factor receptor specifically bind to and are internalized in cells expressing the receptor, and discharge doxorubicin, which reaches the nucleus and exert cytotoxicity. This work opens new perspectives in the use of nanocrystalline apatites as new platform for theranostic applications in nanomedicine.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH