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Bin Zhao, Juan Yan, Dongfang Wang, Zhilei Ge, Shijiang He, Dannong He, Shiping Song and Chunhai Fan Carbon Nanotubes Multifunctionalized by Rolling Circle Amplification and Their Application for Highly Sensitive Detection of Cancer Markers Small 9

Version of Record online: 18 MAR 2013 | DOI: 10.1002/smll.201202957

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Combining carbon nanotubes (CNTs) using DNA rolling circle amplification, the binding ability of proteins, hybridization, the replication ability of DNA, and the catalytical ability of enzymes are all integrated onto a single carbon nanotube. In this system, a large number of signal labels are then allowed to bind to an individual carbon nanotube, resulting in amplified signals. The signaling system shows superior performance in the detection of cancer markers in biological fluids.

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