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Duck-Jin Kim, Hae-Chul Park, Il Yung Sohn, Jin-Heak Jung, Ok Ja Yoon, Joon-Shik Park, Moon-Young Yoon and Nae-Eung Lee Electrical Graphene Aptasensor for Ultra-Sensitive Detection of Anthrax Toxin with Amplified Signal Transduction Small 9

Version of Record online: 16 APR 2013 | DOI: 10.1002/smll.201203245

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A chemically derived graphene field-effect transistor (FET) with aptamer recognition molecules shows ultra-sensitivity (12 aM∼120 fM) for anthrax toxin due to the higher affinity of the aptamer probe compared to that of an Ab probe. Detection capability with a limit of detection (LOD) at the attomolar level (1.2 aM) is achieved due to the amplification of signal transduction by the additional use of the secondary aptamer-conjugated gold nanoparticles (aptamer-AuNPs).

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