Srivani Veeranarayanan, Aby Cheruvathoor Poulose, M. Sheikh Mohamed, Saino Hanna Varghese, Yutaka Nagaoka, Yasuhiko Yoshida, Toru Maekawa and D. Sakthi Kumar Drug Delivery: Synergistic Targeting of Cancer and Associated Angiogenesis Using Triple-Targeted Dual-Drug Silica Nanoformulations for Theragnostics (Small 22/2012) Small 8
A silica nanoparticle-based drug-delivery system developed by D. S. Kumar and co-workers for transporting multiple drugs and imaging agents is armed with tripletargeting ligands, which home in on cancer and angiogenic cells in a collegial fashion. This high-precision, multi-target concept described on page 3476 culminates in an effective therapeutic nanoformulation against breast cancer cells, completely disabling the migration and angiogenic sprouting abilities of activated endothelial cells, achieving both anti-cancer and anti-angiogenic potential in a singular lethal form. This nanoscheme could become the paragon for future cancer/angiogenesis treatment strategies.
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