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Donna Mahony, Antonino S. Cavallaro, Frances Stahr, Timothy J. Mahony, Shi Zhang Qiao and Neena Mitter Mesoporous Silica Nanoparticles Act as a Self-Adjuvant for Ovalbumin Model Antigen in Mice Small 9

Article first published online: 26 APR 2013 | DOI: 10.1002/smll.201300012

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Amino-functionalized mesoporous silica nanoparticles have a high adsorption capacity for ovalbumin. Ovalbumin-bound nanoparticles are used as a delivery system in mice to test their efficacy. Immunization results in both cell-mediated and humoral immunity. The nanoparticles not only act as a protein carrier but also as an effective adjuvant. These results establish mesoporous silica nanoparticles as a viable vaccine delivery vehicle.

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