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Dan Ding, Jie Liu, Guangxue Feng, Kai Li, Yong Hu and Bin Liu Bright Far-Red/Near-Infrared Conjugated Polymer Nanoparticles for In Vivo Bioimaging Small 9

Version of Record online: 26 APR 2013 | DOI: 10.1002/smll.201300171

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Bright far-red/near-infrared conjugated polymer nanoparticles with surface folate ligand and 27% quantum yield in aqueous media are synthesized via a one-step lipid-PEG-folate formulation. The obtained nanoparticles show good thermal/photostabilities and a large Stoke's shift, which compare favorably with commercially available quantum dots (Qdot 655) and organic dyes (Alexa Fluor 555 and Rhodamine 6G), making them a safe and efficient FR/NIR fluorescent probe for targeted in vivo fluorescence imaging and cancer detection in a high contrast and specific manner.

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