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Juan L. Vivero-Escoto, William J. Rieter, Honam Lau, Rachel C. Huxford-Phillips and Wenbin Lin Biodegradable Polysilsesquioxane Nanoparticles as Efficient Contrast Agents for Magnetic Resonance Imaging Small 9

Version of Record online: 24 APR 2013 | DOI: 10.1002/smll.201300198

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The applicability of polysilsesquioxane (PSQ) nanoparticles with cleavable Gd chelates as T1-weighted MRI contrast agents is evaluated in vitro. The chelates are covalently linked via a redox-responsive disulfide moiety, and the platform is further functionalized to improve biocompatibility and cell uptake. The Gd-PSQ particles show high r1 relaxivity values and strong enhancement of T1-weighted images of human lung and pancreatic cancer cells in vitro.

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