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Lucie Pigeon, Cristine Gonçalves, David Gosset, Chantal Pichon and Patrick Midoux An E3-14.7K Peptide that Promotes Microtubules-Mediated Transport of Plasmid DNA Increases Polyplexes Transfection Efficiency Small 9

Article first published online: 10 MAY 2013 | DOI: 10.1002/smll.201300217

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P79-98 peptide responsible for the E3-14.7K/FIP-1 interaction with microtubules is linked to a plasmid DNA to favor its cytosolic migration during cell transfection with a cationic polymer. P79-98 allows docking and transport of DNA along microtubules. P79-98/peGFP polyplexes enhance drastically the number of transfected cells. This is a real breakthrough in the non-viral gene delivery field.

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