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Tianjiao Ji, Ying Zhao, Jing Wang, Xin Zheng, Yanhua Tian, Yuliang Zhao and Guangjun Nie Tumor Fibroblast Specific Activation of a Hybrid Ferritin Nanocage-Based Optical Probe for Tumor Microenvironment Imaging Small 9

Article first published online: 12 JUL 2013 | DOI: 10.1002/smll.201300600

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Ferritin-based FAP-α-responsive fluorescence nanoprobes could be activated immediately as they penetrate the tumor blood vessels and come across the FAP-α molecules on the membrane of CAFs in the tumor microenvironment instead of reaching a certain depth into tumor tissue to interact with tumor cells. This probe may become a promising nanomaterial for highly specific and sensitive tumor imaging through responding to the enzymes in the tumor microenvironment.

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