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Feng Li, Huiling Chen, Lingzhi Ma, Kun Zhou, Zhi-Ping Zhang, Chun Meng, Xian-En Zhang and Qiangbin Wang Insights into Stabilization of a Viral Protein Cage in Templating Complex Nanoarchitectures: Roles of Disulfide Bonds Small 10

Article first published online: 9 SEP 2013 | DOI: 10.1002/smll.201300860

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The origin of robustness: Cysteines at position 9 (C9) and C104 of the major capsid protein (VP1) of simian virus 40 are found to play essential roles in stablizing the viral protein cage as scaffold for assembly of inorganic nanoparticles. The presence of an inorganic core also helps the assembly and stabilization of the protein cage.

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