Ming-Zhen Zhang, Yong Yu, Rong-Na Yu, Min Wan, Rong-Ying Zhang and Yuan-Di Zhao Tracking the Down-Regulation of Folate Receptor-α in Cancer Cells through Target Specific Delivery of Quantum Dots Coupled with Antisense Oligonucleotide and Targeted Peptide Small 9
A new multifunctional quantum dot (QD) probe is prepared by coupled with anti-hFR-α antisense oligonucleotide and targeted peptide p160 with QDs through biotin-streptavidin interaction. Down-regulation of hFR-α in a cell-specific manner is achieved. The probe is effectively transported into the cytoplasm through receptor-mediated endocytosis, and finally antisense oligonucleotides combine with hFR-α mRNA and block the protein translation.
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