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Celina Ansari, Grigory A. Tikhomirov, Su Hyun Hong, Robert A. Falconer, Paul M. Loadman, Jason H. Gill, Rosalinda Castaneda, Florette K. Hazard, Ling Tong, Olga D. Lenkov, Dean W. Felsher, Jianghong Rao and Heike E. Daldrup-Link Development of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy Small 10

Version of Record online: 27 AUG 2013 | DOI: 10.1002/smll.201301456

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The design and characterization of novel multifunctional “theranostic” nanoparticles (TNPs) is described for enzyme-specific drug activation at tumor sites and simultaneous in vivo magnetic resonance imaging (MRI) of drug delivery. TNPs consist of iron oxide core for MR imaging, MMP-14 cleavable peptide linker for specific activation in tumors, and a prodrug that is non-toxic unless activated.

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