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Si-Yong Qin, Jun Feng, Lei Rong, Hui-Zhen Jia, Si Chen, Xiang-Ji Liu, Guo-Feng Luo, Ren-Xi Zhuo and Xian-Zheng Zhang Theranostic GO-Based Nanohybrid for Tumor Induced Imaging and Potential Combinational Tumor Therapy Small 10

Version of Record online: 3 SEP 2013 | DOI: 10.1002/smll.201301613

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A novel theranostic system based on a GO-PEI(Peptide-DOX)-PEG nanohybrid is designed to achieve fluorescent imaging and targeted combinational therapy of tumor cells. Once triggered by the MMP2 enzyme over-expressed in tumor cells, the peptide cleavage permits the liberation of initially locked DOX for targeted chemotherapy and concurrent DOX fluorescence recovery for in situ tumor cell imaging, while co-delivered genes further promote therapeutic efficacy.

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