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Jianfeng Han, Qin Wang, Zhirong Zhang, Tao Gong and Xun Sun Cationic Bovine Serum Albumin Based Self-Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer Small 10

Article first published online: 19 SEP 2013 | DOI: 10.1002/smll.201301992

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Cationic bovine serum albumin based self-assembled nanoparticles are developed to deliver therapeutic siRNA to treat lung metastatic cancer. Interaction between the vehicles and the negatively charged blood components mediates an immediate aggregate formation. This aggregation leads to a primary lung accumulation via the filter effect of capillary beds and the simultaneous dissolution of the aggregates facilitates efficient intracellular siRNA delivery within the lung.

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