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Ali H. Alhasan, Pinal C. Patel, Chung Hang J. Choi and Chad A. Mirkin Exosome Encased Spherical Nucleic Acid Gold Nanoparticle Conjugates as Potent MicroRNA Regulation Agents Small 10

Version of Record online: 17 SEP 2013 | DOI: 10.1002/smll.201302143

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Spherical nucleic acid (SNA) constructs can be naturally sorted into exosomes when endocytosed into PC-3 prostate cancer cells. The exosome-encased SNAs are secreted into the extracellular environment from which they can be isolated and selectively re-introduced into the cell type from which they were derived as potent microRNA regulation agents.

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