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Benjamin M. Davis, Eduardo M. Normando, Li Guo, Lisa A. Turner, Shereen Nizari, Paul O'Shea, Stephen E. Moss, Satyanarayana Somavarapu and M. Francesca Cordeiro Topical Delivery of Avastin to the Posterior Segment of the Eye In Vivo Using Annexin A5-associated Liposomes Small 10

Version of Record online: 5 MAR 2014 | DOI: 10.1002/smll.201303433

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Annexin A5 significantly enhances uptake and transcytosis of liposomal drug carrier systems across multi-layered corneal epithelial barriers. Using a combination of in vitro and in vivo assays, it is demonstrated that Annexin A5 coated liposomes can be employed to deliver physiologically significant concentrations of Avastin to the posterior of the rat and rabbit eye after topical instillation.

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