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Chien-Liang Liu, Tzu-Ming Liu, Tsung-Yuan Hsieh, Han-Wen Liu, Yu-Shing Chen, Cheng-Kun Tsai, Hsieh-Chih Chen, Jong-Wei Lin, Ron-Bin Hsu, Tzung-Dau Wang, Chien-Cheng Chen, Chi-Kuang Sun and Pi-Tai Chou Gold Nanodots: In vivo Metabolic Imaging of Insulin with Multiphoton Fluorescence of Human Insulin–Au Nanodots (Small 12/2013) Small 9

Version of Record online: 14 JUN 2013 | DOI: 10.1002/smll.201370071

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In vivo imaging of insulin metabolism is realized by T.-M. Liu, P.-T. Chou and co-workers using synthesized human insulin–Au nanodots (NDs). Benefiting from its efficient red to near infrared emission, deep tissue subcellular uptake of insulin–Au NDs can be evaluated with a nonlinear optical microscope. On page 2103, insulin-Au NDs permeate into lipid droplets (LDs) of adipocytes, and enlarged ones in type II diabetes mice have a higher adjacent/LD concentration contrast. Human clinical samples show similar trends in patients with diabetes and coronary artery diseas

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