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Helene Bach, Yung-Yu Huang, Mark D. Underwood, Andrew J. Dwork, J. John Mann and Victoria Arango Elevated serotonin and 5-HIAA in the brainstem and lower serotonin turnover in the prefrontal cortex of suicides Synapse 68

Article first published online: 23 JUL 2013 | DOI: 10.1002/syn.21695

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Using high pressure liquid chromatography, we find more brainstem 5-HT and 5-HIAA in suicides compared with nonpsychiatric, sudden death controls throughout the rostrocaudal extent of the brainstem DRN and MRN. This suggests that 5-HT synthesis in suicides is greater within all DRN subnuclei and the MRN compared with controls.

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