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P.O. Fernagut, W.G. Meissner, M. Biran, M. Fantin, F. Bassil, J.M. Franconi and F. Tison Age-related motor dysfunction and neuropathology in a transgenic mouse model of multiple system atrophy Synapse 68

Version of Record online: 15 NOV 2013 | DOI: 10.1002/syn.21719

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This work demonstrates that a genetic mouse model of multiple system atrophy recapitulates some of the progressive features of the disease, including age-related behavioural impairments and brain atrophy, together with a high burden of alpha-synuclein accumulation in the basal ganglia. This study delivers endpoints for the evaluation of therapeutic strategies.

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