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Ling Chen, Zhihua Wang, Bo Tang, Min Fang, Jie Li, Guojun Chen and Xuefeng Wang Altered expression of c-Abl in patients with epilepsy and in a rat model Synapse 68

Version of Record online: 2 APR 2014 | DOI: 10.1002/syn.21741

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Using double immunolabeling, immunohistochemistry, and immunoblotting, we found that c-Abl was expressed in the membrane and cytoplasm of neurons and both total and phosphorylated c-Abl was upregulated in patients with TLE. In experimental rats, c-Abl levels increased from 6 h to 60 days postseizures. These data implicate that c-Abl may play a role in the development of TLE.

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