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Shingo Nishiyama, Hiroyuki Ohba, Tatsuhiro Kobashi, Yumi Nakamasu, Hidekazu Nakao, Tokutaro Ogata, Takeru Kitashoji and Hideo Tsukada Development of novel PET probe [11C](R,R)HAPT and its stereoisomer [11C](S,S)HAPT for vesicular acetylcholine transporter imaging: A PET study in conscious monkey Synapse 68

Article first published online: 12 APR 2014 | DOI: 10.1002/syn.21743

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[11C](R,R)HAPT and its stereoisomer [11C](S,S)HAPT were developed for imaging vesicular acetylcholine transporters (VAChT), located in presynaptic cholinergic neurons in the brain. [11C](R,R)HAPT binding in the monkey brain was displaced by vesamicol, a specific VAChT antagonist, but not by SA4503, a sigma-1 agonist, suggesting the specificity of [11C](R,R)HAPT to VAChT.

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