Hermes Pofantis and Costas Papatheodoropoulos The α5GABAA receptor modulates the induction of long-term potentiation at ventral but not dorsal CA1 hippocampal synapses Synapse 68
In this study the ability of CA1 synapses for 10Hz-induced long-term potentiation (LTP) was examined in dorsal and ventral hippocampal slices. Under control conditions (naive) dorsal slices displayed larger LTP compared with ventral slices. Remarkably, blockade of α5GABAA Ps by L-655,708 greatly enhanced the ability for LTP in the ventral hippocampus only.
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