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Li Jie, Jiang Guohui, Yalan Chen, Ling Chen, Zengyou Li, Zhihua Wang and Xuefeng Wang Altered expression of hypoxia-Inducible factor-1α participates in the epileptogenesis in animal models Synapse 68

Article first published online: 17 JUN 2014 | DOI: 10.1002/syn.21752

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Behavior changes showed that the spontaneous seizure times of HIF-1α agonist DMOG-treated group were significantly decreased compared with those of the control groups during the chronic period in the lithium-pilocarpine epilepsy model. Conversely, its inhibitor KC7F2 produced an opposite behavioral change.

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