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Hirota Fujiki Green tea: Health benefits as cancer preventive for humans The Chemical Record 5

Article first published online: 11 MAY 2005 | DOI: 10.1002/tcr.20039

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Cancer is, of course, an urgent medical problem, but recent developments in understanding carcinogenesis have shown the possibility of cancer prevention. This paper looks at green tea as a cancer preventive, presenting our results showing that the (−)-epigallocatechin gallate (EGCG) in green tea inhibited phorbol ester receptor binding, activation of protein kinase C, and tumor promotion. Mechanisms of EGCG are discussed, with emphasis on the “sealing effects” that seem to reduce tumor necrosis factor-α gene expression. We recommend 10 Japanese-size cups of green tea daily as a cancer-preventive dose.

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