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Takao Ikariya and Ilya D. Gridnev Bifunctional transition metal-based molecular catalysts for asymmetric C[BOND]C and C[BOND]N bond formation The Chemical Record 9

Version of Record online: 20 MAR 2009 | DOI: 10.1002/tcr.20172

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New bifunctional chiral Ru and Ir catalysts effectively catalyze enantioselective Michael addition of 1,3-dicarbonyl compounds to cyclic enones and nitroalkenes, and enantioselective direct amination of α-cyanoacetates with diazoesters. Convenient synthetic procedures allow multigram scale syntheses of practically important chiral compounds. Stereoselection takes place through building a three-dimensional chiral pocket in the complex formed in the reaction of the catalyst with a pronucleophilic reagent.

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