Charles E Massie, Andy Lynch, Antonio Ramos-Montoya, Joan Boren, Rory Stark, Ladan Fazli, Anne Warren, Helen Scott, Basetti Madhu, Naomi Sharma, Helene Bon, Vinny Zecchini, Donna-Michelle Smith, Gina M DeNicola, Nik Mathews, Michelle Osborne, James Hadfield, Stewart MacArthur, Boris Adryan, Scott K Lyons, Kevin M Brindle, John Griffiths, Martin E Gleave, Paul S Rennie, David E Neal and Ian G Mills The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis The EMBO Journal 30
Article first published online: 20 MAY 2011 | DOI: 10.1038/emboj.2011.158
Using a combination of genomic and metabolomic profiling strategies, the CAMKK2 kinase is identified as a critical downstream target of the androgen receptor. CAMKK2 regulates anabolic flux, and represents an attractive therapeutic target for prostate cancer treatments.
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