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Joseph JB Cockburn, M Erika Navarro Sanchez, Ana P Goncalvez, Elena Zaitseva, Enrico A Stura, Carlos M Kikuti, Stéphane Duquerroy, Philippe Dussart, Leonid V Chernomordik, Ching-Juh Lai and Felix A Rey Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus The EMBO Journal 31

Version of Record online: 2 DEC 2011 | DOI: 10.1038/emboj.2011.439

The envelope (E) protein of Dengue virus is essential for virus entry, and various neutralizing antibodies have been identified that target this protein. Structural analysis of a chimpanzee antibody in complex with the E protein elucidates its mechanism of inhibition, providing a potential basis for vaccine design.

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