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Cornelia Hömig-Hölzel, Remco van Doorn, Celia Vogel, Markus Germann, Marco G Cecchini, Els Verdegaal and Daniel S Peeper Antagonistic TSC22D1 variants control BRAFE600-induced senescence The EMBO Journal 30

Article first published online: 29 MAR 2011 | DOI: 10.1038/emboj.2011.95

Based on their original genome-wide transcriptome analysis of oncogenic BRAF, Peeper et al report here on TGFβ-stimulated clone 22 (TSC22) transcripts as novel mediator of oncogene-induced senescence triggered by TGFβ, oncogenic RAS and BRAF. The TSC22D1 transcript acts downstream of CEBP/β in the control of senescence-associated pro-inflammatory cytokine and p15INK4b expression.

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