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Emma Sandilands, Bryan Serrels, Simon Wilkinson and Margaret C Frame Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells EMBO reports 13

Article first published online: 26 JUN 2012 | DOI: 10.1038/embor.2012.92

Ret is shown to be a Src-dependent autophagy substrate upon defective FAK signalling, when Src is known to induce its own autophagic degradation. Thus, Src is a general mediator of FAK-binding kinase degradation under adhesion stress, enabling cancer cell survival.

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