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Manu Vanaerschot, Silvie Huijben, Frederik Van den Broeck and Jean-Claude Dujardin Drug resistance in vectorborne parasites: multiple actors and scenarios for an evolutionary arms race FEMS Microbiology Reviews 38

Version of Record online: 22 JUL 2013 | DOI: 10.1111/1574-6976.12032

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This review demonstrates the multiplicity of scenarios that occur during the natural history of drug resistance in vectorborne parasites, which not only result from the biological diversity of the different organisms (such as their genome organisation, reproduction mode and life-cycle characteristics), but also from the different modes of action of the drugs used (targeting vulnerable points of their metabolism or key natural defences of the pathogens and thus further boosting pre-existing adaptations), their own specific within- and between-host ecology and environmental factors acting directly (e.g. chemical pollution) or indirectly (through an effect on transmission) on the parasites.

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