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Stefan Wieschalka, Bastian Blombach, Michael Bott and Bernhard J. Eikmanns Bio-based production of organic acids with Corynebacterium glutamicum Microbial Biotechnology 6

Version of Record online: 2 DEC 2012 | DOI: 10.1111/1751-7915.12013

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Corynebacterium glutamicum is well known as workhorse for the industrial production of amino acids. Recent studies also explored the usefulness of this organism for the production of several organic acids and great efforts have been made for improvement of the performance. This review summarizes the current knowledge and recent achievements on metabolic engineering approaches to tailor C. glutamicum for the bio-based production of pyruvate, L- and D-lactate, 2-ketoisovalerate, 2-ketoglutarate, and succinate.

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