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Des Field, Evelyn M. Molloy, Catalin Iancu, Lorraine A. Draper, Paula M. O' Connor, Paul D. Cotter, Colin Hill and R. Paul Ross Saturation mutagenesis of selected residues of the α-peptide of the lantibiotic lacticin 3147 yields a derivative with enhanced antimicrobial activity Microbial Biotechnology 6

Version of Record online: 25 FEB 2013 | DOI: 10.1111/1751-7915.12041

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Saturation mutagenesis of specific residues of Ltnα established that it is more tolerant to change than previously suggested by alanine scanning mutagenesis. One substitution LtnαH23S, was identified which improved the specific activity of lacticin 3147 against one pathogenic strain, representing the first occasion upon which the activity of a two peptide lantibiotic has been enhanced through bioengineering.

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