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Mia C. Hikke, Marjan Verest, Just M. Vlak and Gorben P. Pijlman Salmonid alphavirus replication in mosquito cells: towards a novel vaccine production system Microbial Biotechnology 7

Article first published online: 14 JAN 2014 | DOI: 10.1111/1751-7915.12100

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Salmonid alphavirus (SAV) causes pancreas disease and sleeping disease in Atlantic salmon and rainbow trout and confers a major burden to the aquaculture industry. Here, we show for the first time that SAV is able to complete a full infectious cycle within arthropod cells derived from the Asian tiger mosquito Aedes albopictus. Besides the biological importance of this observation, the use of invertebrate cells provides a putative alternative production platform for SAV vaccines.

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