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Laxmi Yeruva, Nicole Spencer, Anne K. Bowlin, Yin Wang and Roger G. Rank Chlamydial infection of the gastrointestinal tract: a reservoir for persistent infection Pathogens and Disease 68

Version of Record online: 10 JUL 2013 | DOI: 10.1111/2049-632X.12052

In this paradigm shifting study, the authors confirm that chlamydiae can efficiently infect the gastrointestinal tract (of mice in this case but potentially all hosts, including humans) and remain there as chronic infections for significant lengths of time. While the host might mount an initial immune response, this does not eliminate the infection. This “silent” GI tract infection by Chlamydia could result in subsequent reinfections, not only of the gastrointestinal tract but also the genital tract, altering the way we view host immune response to this pathogen.

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