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Lena H. Ernst, Michael M. Plichta, Thomas Dresler, Anna K. Zesewitz, Sara V. Tupak, Florian B. Haeussinger, Matthias Fischer, Thomas Polak, Andreas J. Fallgatter and Ann-Christine Ehlis Prefrontal correlates of approach preferences for alcohol stimuli in alcohol dependence Addiction Biology 19

Version of Record online: 12 NOV 2012 | DOI: 10.1111/adb.12005

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In an Approach-Avoidance Task, alcohol dependent patients showed stronger behavioural approach preferences for alcohol than non-alcohol stimuli. For non-alcohol stimuli, patients even displayed avoidance preferences. The reversed pattern was found in healthy controls. Group differences in activity of the OFC as measured with functional near-infrared spectroscopy were identical to those in RTs, revealing patients to assign higher subjective value to approaching alcohol stimuli. In both groups, regulatory activity in the right DLPFC was stronger during avoiding than approaching alcohol pictures.

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