Amanda Elton, Jonathan Young, Sonet Smitherman, Robin E. Gross, Tanja Mletzko and Clinton D. Kilts Neural network activation during a stop-signal task discriminates cocaine-dependent from non-drug-abusing men Addiction Biology 19
Cocaine dependence is defined by deficits in inhibitory behavioral control. We assessed whether patterns of neural processing related to inhibitory motor control reliably and accurately discriminate cocaine-dependent and control samples of men. An independent component analysis of fMRI time courses identified neural processing networks associated with five sub-processes of the stop-signal task. Linear discriminant analysis was used to train and independently test an accurate multivariate pattern classifier. Cocaine addiction classification scores predicted trait impulsiveness and level of lifetime cocaine use.
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