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Blake A. Kimmey, Laura E. Rupprecht, Matthew R. Hayes and Heath D. Schmidt Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats Addiction Biology 19

Article first published online: 12 DEC 2012 | DOI: 10.1111/adb.12014

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A growing literature indicates that cognitive deficits represent a core symptom of nicotine withdrawal that predict relapse during smoking abstinence. However, the effects of cognitive-enhancing medications on nicotine taking and seeking are not clear. Here, we show that systemic administration of the acetylcholinesterase inhibitor donepezil, which improves cognitive performance in smokers, attenuated nicotine self-administration and the reinstatement of nicotine-seeking behavior in rats. These results suggest that donepezil may prevent smoking relapse in abstinent human smokers.

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