E-mail a Wiley Online Library Link

Blake A. Kimmey, Laura E. Rupprecht, Matthew R. Hayes and Heath D. Schmidt Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats Addiction Biology 19

Article first published online: 12 DEC 2012 | DOI: 10.1111/adb.12014

Thumbnail image of graphical abstract

A growing literature indicates that cognitive deficits represent a core symptom of nicotine withdrawal that predict relapse during smoking abstinence. However, the effects of cognitive-enhancing medications on nicotine taking and seeking are not clear. Here, we show that systemic administration of the acetylcholinesterase inhibitor donepezil, which improves cognitive performance in smokers, attenuated nicotine self-administration and the reinstatement of nicotine-seeking behavior in rats. These results suggest that donepezil may prevent smoking relapse in abstinent human smokers.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field