Camron D. Bryant, Michael A. Guido, Loren A. Kole and Riyan Cheng The heritability of oxycodone reward and concomitant phenotypes in a LG/J × SM/J mouse advanced intercross line Addiction Biology 19
The conditioned place preference assay (CPP) is frequently used to study opioid reward in genetically engineered mice; however the contribution of natural genetic variation to opioid CPP is unknown. Here, oxycodone-induced CPP was not a significantly heritable trait in an advanced intercross line (AIL) derived from LG/J and SM/J strains. In contrast, other oxycodone-induced traits were heritable, including oxycodone-induced locomotor activity (D2 ACT, D4 ACT), locomotor sensitization (D4-D2 ACT), and transitions to the oxycodone-paired side during CPP (SD CHG D8).
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